| Product name |
Lovastatin |
| CAS No. |
75330-75-5 |
| Purity |
99% |
| Appearance |
White powder |
| Application |
API |
| Package |
Plastic bags |
| Storage |
Store in a closed container in a cool and dry place, below 5ºC. |
| Retest Date |
2 years |
1. Lipid-regulating effect
Lovastatin blocks the synthesis of endogenous cholesterol by inhibiting HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, and reduces the cholesterol content in cells. It increases the number of LDL receptors on the cell surface in a feedback manner, accelerates the uptake and degradation of LDL particles in the blood circulation, and reduces total cholesterol and very low-density lipoprotein (VLDL), LDL and triglycerides in plasma. Since the conversion of HMG-CoA to mevalonate is an early step in the cholesterol biosynthesis pathway, the use of lovastatin will not cause the accumulation of potentially toxic cholesterol substances, and HMG-CoA can also be quickly reversely metabolized into acetyl coenzyme A and participate in other biosynthesis pathways in the body. This inhibitory effect is incomplete and reversible, and there is a dose-effect relationship. At the therapeutic dose, it will not affect the amount of cholesterol required for the normal function of the cell membrane. Therefore, lovastatin has a significant lipid-lowering effect with fewer side effects.
In general, lovastatin plays a role in the following aspects: 1.competitively inhibiting HMG-CoA reductase activity and reducing endogenous cholesterol synthesis; 2. increasing the expression of hepatocyte LDL receptors and improving the receptor-mediated clearance rate of plasma LDL; 3. inhibiting the migration and proliferation of smooth muscle cells; 4. reducing the assembly and secretion of liver lipoproteins.
2. Non-lipid-regulating effect
In addition to its significant lipid-lowering effect, lovastatin can also significantly improve the function of endothelial cells, promote the production of nitric oxide synthase (eNOS), and thus increase the synthesis and release of NO, which plays a key role in maintaining normal pulmonary vascular tension and reversing hypoxia-induced pulmonary vasoconstriction and vascular remodeling. In addition, lovastatin has anti-inflammatory and anti-proliferative effects, and can inhibit the proliferation of renal mesangial cells and the secretion of extracellular matrix, thereby achieving the purpose of alleviating glomerular sclerosis.
Hubei Highwin New Material Technology Co., Ltd. focuses on the research and development, production and sales of epoxy resin and other chemical raw materials. We have been rooted in chemical raw materials for more than 20 years and have already been one of the top suppliers in China after years of efforts. There are a group of hard-working, motivated, and creative staff working not only for the company but also for you-our respectable customer and partner! Based on good service and high-quality products, we're widely praised and trusted by customers and keep long-lasting relationships with them.
Our enduring commitment is "Providing customers worldwide with the highest quality chemical raw materials and the most professional procurement services "!
Our ever-lasting vision is to "Obtain a wide range of customer resources through high-quality procurement and the best service, and establish a sustainable and stable customer relationship"!
We aim to grow responsibly and believe we can build a good ethos and benchmark for the raw material industry!
For over 20 years, we stick to the research and development, production and sales of chemical raw materials, especially high-purity epoxy resins, benzyl alcohol as well as epoxy reactive diluents. Know, we have processed a keen insight into the industry trends through long-term persistence. Our products are mainly used in the manufacture of industrial, paint, pharmaceutical, cosmetic, and other composite materials. What's more, in addition to supplying you with existing raw materials, we can also find the products you need and work with you to create better production solutions. Our responsibility is not only to provide you with high-quality products but also to solve your problems!
we have more than 20 years of experience and have never given up even if it is not so easy, which is not very common among our peers. Therefore, we have a long-term and very stable relationship with many manufacturers in China, which can provide you with a high-quality and solid supply chain.
We provide high-quality chemical raw materials and professional service for global industrial, coating, pharmaceutical, cosmetic, and compliant material manufacturers and major distributors, helping you to solve the difficulties in finding high-quality chemical raw materials and saving your time and cost so as to achieve a higher level of research and development and production.
Powder:1kg Aluminum Foil Bag
25kg drum/bag
Liquid: 1L Bottle
25L drum
200L drum
OEM&ODM for product packaging is accepted.
- ≤50kg, Express delivery recommended, usually called as DDU service;
- ≤500kg,Air shipping recommended, usually called as CIF service;
- >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;
- For high value products, please select air shipping and express delivery for safety.
Accept the shipping method specified by the customer.
And We can also recomend you the best shipping method to let you receive the products more safely and faster.
1.Can a get a free sample ?
We can provide you with free samples, you only need to pay for the shipping cost.
2.How can I trust you ?
Our owner has over 20 years of experience in the chemical raw materials field as well as our staffs. It is because of the trust of our customers and partners that we have been able to exist and develop for so many years. Our ever-lasting vision is to 'Obtain a wide range of customer resources through high-quality procurement and the best service, and establish a sustainable and stable customer relationship'!
3.How do you guarantee the quality of your products?
All of our products comply with national testing standards and international standards. If you need, we can provide you with certificates.
4.Can you use customer-specific labeling and packing?
Of course, you can provide us with the specified labeling and packaging and we will be happy to follow up with you.assist you. If there is anything else you need, please feel free to communicate with us!
5.How about delivery time and method?
We usually ship within 3-5 working days after payments.
We can make ships by sea, air, or express. Also can make door-to-door shipping.
My name is Clara ! Welcome your kind inquiry and orders from us !
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