Pharmacuetical Raw Powder Mirabegron CAS 223673-61-8 GMP Grade

• Customization: Available
• CAS No.: 223673-61-8
• Formula: 223673-61-8
• Model NO.: CAS 223673-61-8
• Type: Synthesis Material Intermediates
• Appearance: Liquid
• Quality: Industrial
• Colour: White
• Model No.: 223673-61-8
• Sample: Available
• Delivery: 15 Days
• Transport Package: Bag
• Specification: Bag
• Trademark: HIGHWIN
• Origin: China
• Production Capacity: 30000ton/Year

Product Description

Product Parameters

Product Name: Mirabegron
CAS: 223673-61-8
MF:C21H24N4O2S
MW:396.51
EINECS:800-126-3
MDL No.:MFCD11100356
Melting point:138-140°C
Boiling point:690.0±55.0 °C(Predicted)
Density 1.313
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka13.51±0.70(Predicted)
form Solid
color White to Pale Yellow
Purity: 99%
Package:  100g;1kg;5kg

Product Name:	Mirabegron
CAS:	223673-61-8
MF:	C21H24N4O2S
MW:	396.51
EINECS:	800-126-3
Mol File:	223673-61-8.mol

Mirabegron is for the treatment of urgency, urinary frequency, and urinary urge urinary incontinence associated with overactive bladder (OAB). Mirabegron is synthesized by coupling 4-nitrophenethyl amine to (R)-2-hydroxy-2-phenylacetic acid. The resulting amide is reduced to an amine. The nitro group is then reduced and the resulting is coupled to 2-(2-aminothiazol-4-yl) acetic acid to give mirabegron. Mirabegron has an EC50 of 22 nM (intrinsic activity=0.8) for β3-AR with no detectable activity for β1- andβ2-AR (EC50>10,000 nM). In an anesthetized rat rhythmic bladder contraction model in which bladder contractions are induced by saline, mirabegron at 3 mg/kg iv decreased the frequency of rhythmic bladder contraction without suppressing contraction amplitude. These data suggest that the activation of β3-AR increases bladder capacity without influencing the frequency of bladder contraction.

Application

1.Mirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.
2.Uses for A potent bladder relaxant compound
3.Uses for Potent bladder relaxant and reagent for diabetes remedy.;Labeled Mirabegron, intended for use as an internal standard for the quantification of Mirabegron by GC- or LC-mass spectrometry.

Packaging & Shipping

 

 

Hubei Highwin New Material Technology Co., Ltd.focuses on the research and development, production and sales of epoxy resin and other chemical raw materials. We have our own R&D laboratory, by ordinating our suppiers all over the world and manufacturing products with cooperatedbased factories, we're keeping enhance our competitiveness in the market. Before developing overseas sales, we have been rooted in chemical raw materials for more than 20 years and have already been one of the top suppliers in China after years of efforts. There are a group of hard-working, motivated, and creative staff working not only for the company but also for you--our respectable customer and partner! Based on good service and high-quality products, we're widely praised and trusted by customers and keep long-lasting relationships with them. We aim to grow responsibly and believe we can build a good ethos and benchmark for the raw material industry!

FAQ

FAQ:
Q1: Can I get samples?
A: Yes, we can provide you with free samples, but the freight needs to be paid by you, I hope you can understand.
Q2: How to pay?
A: PI will be sent firstly after our aligned products specification. Payment by Paypal , T/T, Western Union,LC, are ok.
Q3: How is your MOQ?
A: Normally speaking, our MOQ is 1kg. But we can also accept less quantity such as 100g on the condition that sample charge is100% paid.
Q4: How can you guarantee the quality of your products ?
1. Our staff are all experienced in chemical products or related major background, they are well trained before quotation.
2. Free sample or pre-shipment sample are available for our new cooperation before you place commercial order. We are sure the same specification commercial products as sample to customers
3. Third Party Inspection like SGS can be arranged according to your requirement before shipping.
4. On-Spot QC in our APPROVED associated production bases with necessary certification like GMP, ISO etc.
Q5:How is your after-sales service?
A: If you have any technical or quality problems after receiving the goods, you can always contact us. If the problem is caused by us, we will send you the goods for free or refund your loss.